If you want to build user interfaces, I'd recommend learning Cocoa or Qt, which are both well-designed UI libraries. (Java/Swing is okay, but Win32 has a limiting design, and MFC is crap. Was pretty unimpressed with Android's UI, but haven't really used it enough to have a quality opinion.) HTML was designed for documents and its model is unsuited for UI. If you're going to learn for research first, then in my opinion you'd be better off learning how to do it right, and then if you still want to use the DOM, you'll have a better idea on what would be an effective framework to make/use.