Hell, cyberpsychosis, a pretty plot-minor series of encounters, delves into one of the more interesting considerations in the game. That a fair number of people are unable to handle the implant tech at all and lose their ability to function in a balanced way - each encounter has a harrowing series of notes about the person degrading into insanity and each is just sort of... ignored by most of the people around it and accepted as a cost of technological advancement.

I know the devs get a lot of hate, but I think that there is a whole lot of heart and soul poured into that game.