In the absence of larger issues, maybe. What if you're one of very few minorities or women working at the company, and the issues seems to stem from issues that shouldn't be issues? That seems more like a company problem and not a personal or cultural problem (given that the culture in question has laws to try to prevent it).

I agree it's probably best to start from a position that it's just a cultural mismatch. I imagine sometimes it gets entangled with a lot of other issues though, whether rightfully so or in perception only.

I think even in those situations, telling them that you never felt like you fit is still the right approach. I there is actual wrongdoing, report them. But if it's a boy's club, it's probably better to phrase it as such than point to each individual actor as sexist.

I think at least in American companies, it's hard to tell whether your co-workers are actually happy, or if they are putting on the expected corporate ExcitedToBeHere persona. You ask 200 co-workers "How's it going?" and you're going to get 200 variations of: "You know, really busy, but it is super-exciting to be meeting KPIs and synergizing the latest roadmap with our external stakeholders, blah, blah, blah." Ain't nobody saying "Well, you know, Bob, things are pretty shitty for me because I spent the last quarter working my butt off and Lumburgh gave the promotion to that idiot he's been banging in the conference room every evening."

Being honest opens you up to having that honesty used against you, so people just put on a cheerful saccharine smile and lie.

Also, answering the question can help you find what you are looking for.