I've used Reason since 2001. For a while I had a desktop PC for DAW stuff, and I mostly ran Cubase w Reason w Motu 828 MK2. Cubase + windows bugs drove me crazy. Once Reason supported audio I ditched Cubase and went onto Mac OS. I would highly recommend Reason as I think they have the best overall offering plus the quality is amazing - almost never encountered a bug or issue when using it. There are a lot of options these days so it kinda depends on what you want to do.