The Uselessness of Phenylephrine

Re:The Uselessness of Phenylephrine by ratsmack on Wednesday March 30, 2022 @04:28PM (#30860380)

This is especially important when it comes to children. This is because kids vary in weight in relation to age more than adults do, but the vast majority of drugs are dosed by age. This is just insanity at it's finest.

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Re:The Uselessness of Phenylephrine by cwkoss on Wednesday March 30, 2022 @04:34PM (#30860441)

Yep, and that's only using the rough metric of bodyweight. There are a number of other major factors like size and health of liver, whether the patient has any under/over expression of metabolic enzymes, etc that can further complicate the determination of proper dosage.

Would be super cool if we had an objective measure of proper dosage - such as blood concentration or excreted metabolites - to give us more insight into how the drug is being metabolized by the individual.

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Re:The Uselessness of Phenylephrine by simulate-me on Wednesday March 30, 2022 @04:35PM (#30860457)

Is there any evidence that harm is being caused from age-based dosing?

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