Well, I've spent the last few days coding with Twitter's Bootstrap and the Dojo toolkit and both are a pain to use. Bootstrap is too controlling, only supports the latest browsers, and has a very non-intuitive grid system. Dojo takes the kitchen sink approach yet doesn't offer a lightweight grid system so you're forced to look for alternatives.

So yeah, we need another js/html framework, maybe this time it actually delivers on its promises. I'm intrigued by the focus on jQuery, HTML 5 and supporting mobile devices, but I'm not going to start using this framework as of yet.