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Re:Old Spleens Suck (2021) by echelon on Friday March 25, 2022 @11:49PM (#30809099)
Spleens are one of the more vulnerable organs. They're prone to rupture during trauma, and if ruptured, can easily cause a person to bleed out. In many motorcyclist accidents, a ruptured spleen can be the cause of death.

Spleens are essentially large bags of blood and immunological pulp, and the reason they evolved this way is because they act as a filter against bloodborne pathogens. They host a diverse but specialized collection of immune cells, such as macrophages, and have a truly unique and interesting role in overall health.

You should read up on the thymus next. That one is super important and is also implicated in aging.

Re:Old Spleens Suck (2021) by outworlder on Saturday March 26, 2022 @12:17AM (#30809194)
> You should read up on the thymus next. That one is super important and is also implicated in aging.

That one seems to self-deactivate with age.

Re:Old Spleens Suck (2021) by echelon on Saturday March 26, 2022 @02:08AM (#30809656)
Indeed. The thymus is responsible for much of our immune cell production, but it shrivels away to nothing by our elderly years.

It's unfortunate, because our responses to immune challenges - including cancer - diminish with age.