Time ago, when OpenSolaris dead I've switched to Ubuntu, until Unity (WM) was there it was good enough, after they took "the enterprise path", I'm on NixOS, there are a bit of annoyances to run unpackaged binaries but the rest work like a charm AND it's fully reproducible AND creating a custom iso is just the config + a oneliner, so deploy a personal desktop/homeserver is as easy as deploy in an enterprise automated infra without the burden of it.

The nix language is indigestible for me, so I eye Guix System but so far Guix does not have things I like/need so still on NixOS in a calm state: systems updated, automated, reproducible without thinking and babysitting them continuously.