That's not a definite conclusion, but it seems reason enough not to necessarily hanker over one specific psychedelic if you've never done any of them. You'll probably have a profound enough experience on any classic psychedelic.
By the way, cannabis can be psychedelic in high enough doses (especially when eaten), so that might be a way to go for you, considering it's legal in so many places.. and it's generally a lot safer to get cannabis on the above-ground market than some mystery substance on the black market.
Depending on where you go, other psychedelics could also be legal. Dig deep and ye shall probably find. Just do some thorough research on what you're getting into, particularly on testing substances to make sure you're getting what you think you're getting, and on how to do them safely.
A few states are legalizing psilocybin, that'd be the way to go.
This is a great and very important question. There'd be a lot fewer deaths and adverse reactions if more people took it seriously.
For one, you could study chemistry and pharmacology and synthesize the compounds yourself.
Second, you could test the compounds you got. There are testing kits you can buy and testing services (like those done by DanceSafe at festivals), but while they can test for known compounds, they can't test for unknown ones (like many of the new designer drugs that aren't well known yet)... and they generally don't test for potency either.
Third, you could grow or pick some natural psychedelics, like mushrooms, cacti, and various plants. You have to be really careful with this and really know what you're doing or rely on someone who does. Alan Rockefeller's talks on identifying psilocybin mushrooms are great for this: [1]
Fourth, some psychedelics like morning glory seeds, hawaiian baby woodrose seeds, salvia divinorum, and ketamine can be acquired legally in many places. 5-MeO-DMT itself is legal in some places. So where these are legal you should be more assured of their safety -- though you'll still want to make sure the seeds are pesticide-free, for example.
Finally, anyone who cares about safety should be advocating legalization, as it's keeping these substances illegal that makes them less safe and leads to many unnecessary deaths and overdoses.
But more generally speaking, a person has to gauge the safety of a drug they buy on their knowledge of the source. Ideally, it's via someone who has purchased from that source before and can vouch for the drugs.
Unfortunately, that has not been the case, as there are now very potent and potentially lethal drugs like Bromo-DragonFLY[1] that are active in similar dosages to LSD.
So you really need to test what you get.
Both these descriptions of dose are meaningless. A typical dose of LSD is anywhere between 50 and 300 micrograms. But with such a minuscule amount being so potent it is deceptive when considering what a lethal overdose of LSD is. I've heard it said you'd have to literally drown in LSD for it to kill you. I expect the actual lethal dose is an estimation, because even 500x the normal dose is apparently not lethal.
Even cannabis is illegal there, although it has been decriminalised for personal use, and its sale is tolerated under certain conditions.