We run on thousands of EC2 instances and our biggest systems operate at millions of requests/sec. No containers*. We use EC2, Route53, S3, and some other AWS stuff, plus custom tooling built on their APIs. Most of our code is Go or Clojure so deployments generally consist of self-contained artifacts (binary or jar) plus some config files; there's little to no customization of the instance for the application.

*Well we do have an in-house job queue system that runs jobs in Linux namespaces for isolation. But it doesn't use Docker or whole-OS images at all.