I have those 6 screens plugged to two different macs, so just 3 on each. Big screen in the center, and two in portrait mode on the sides. One uses 43" 4k for the center screen, the other uses a 34" ultrawide.

The m1 max drives its displays directly, the m1 via a starlink tripple 4k displaylink hub.

The problems, in my case, are specific to monitors that take a good few seconds to come back from standby. Macos seems to be impatient and considers them dead. I am down to just 1 screen with this problem, and will replace it at some point.