It depends. If you don't have any problems with RSI or other similar conditions I would recommend against switching layouts, as there has never been conclusive studies to demonstrate that any other layout is faster for typing than QWERTY and transitioning takes a significant amount of time. If you do have issues with QWERTY I would first recommend an ergonomic keyboard (particularly a split board with as many adjustments as necessary), and if that fails then another layout may be necessary. Anecdotally a lot of people have benefited from switching layouts, but usually it's more hassle than it's worth.