Lots of people use python apps and not know about it. I don't get where the idea that it's complicated comes from. You run them the same way as everything else. For example if you use anything redhat-based you're running a python app (https://github.com/rpm-software-management/dnf). If you're running any desktop environment, you're likely using at least one python app or something with python scripting embedded.
Not sure what this is really on about, you can easily run a python program opaquely to a user by packaging it as an executable… or simply including #!/usr/bin/env python3 in a shell file and then `chmod +x script.py` on Linux.
But to answer your question, yes, millions of people run Python programs without ever knowing anything about Python.
Put everything in the standard library, or nothing at all, it doesn't really matter. Either way you still have to set up a custom environment and install a bunch of extra stuff and learn "how to run Python programs".