It will take fundamental advances to get to p-11B fusion. A startup working today is anyway in no position to achieve such fundamental advances; that is more in the line of national laboratories, or would be if they were not fooling with ITER instead. Maybe some of the ITER work will be useful for other things.

For D-3He fusion to be useful, we have to hope that it will be economically viable to synthesize 3He, in the meantime. Arguably, we ought to be making and stockpiling tritium now so there will be enough 3He when we need it; but that might be too optimistic.