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Re:Ketamine for the acute treatment of severe suicidal ideation by skissane on Monday March 14, 2022 @05:26PM (#30678566)
You generally can’t compare recreational and prescribed drug use, even for the same substance, because the doses tend to be widely different.

A lot of people take amphetamines as a medically prescribed treatment for ADHD (and other conditions such as narcolepsy too). A lot of people take amphetamines recreationally. Studies done on the negative heath consequences for recreational users are largely irrelevant to medically prescribed users, because your average recreational dose is an order of magnitude (or more) higher than the average prescribed dose. Increase the dose ten-told, it acts like a different drug altogether.

Plus, the irregular dosing schedule of recreational users probably isn’t helping either. And many recreational users try to get the drug into their bloodstream as fast as possible (injection, snorting, smoking), while most prescription drugs aim to be released more gradually (oral route, sometimes even extended release or an inactive prodrug such as Vyvanse/lisdexamfetamine)

Re:Ketamine for the acute treatment of severe suicidal ideation by netizen-936824 on Monday March 14, 2022 @05:56PM (#30678955)
The person you're replying to, from my interpretation, is saying that their friend had a ketamine infusion at a clinic. Nowhere do they mention recreational use
Re:Ketamine for the acute treatment of severe suicidal ideation by chimeracoder on Monday March 14, 2022 @06:15PM (#30679152)
> Studies done on the negative heath consequences for recreational users are largely irrelevant to medically prescribed users, because your average recreational dose is an order of magnitude (or more) higher than the average prescribed dose. Increase the dose ten-told, it acts like a different drug altogether.

What you're saying applies in other cases, but in the case of ketamine, the recreational dose is one or two orders of magnitude lower than the clinical dose.