One established business and another startup I worked at absolutely thrived explicitly because we built web applications rather than native ones.

In the first case, we kept it narrowly tailored to two pages that absolutely needed that level of interactivity. In the second, requiring customers' employees to install an app on their phones would have been a non-starter during the sales process, and the lack of an app was a major selling point for others.

YMMV- oddly enough, both made use of the canvas element in critical parts (these were not simple CRUD websites).