I'd say this is essentially the cause of burnout in, well, life in general.

The same applies to any sustained pursuit, be it a hobby, work, relationship (romantic or otherwise), family relations, etc.

If you constantly bash your head against a wall and factors outside of your control conspire to mean that you make no or little progress and receive no or little reward then you need to stop.

Burnout is your body's way of forcing you if you persist.