I have this monitor too and love it, but there is one major caveat -- the USB hub only operates at USB 2.0 speeds (480Mbps) when using a single cable for both display and USB.
This is an important caveat, but one I haven't stumbled over yet (I use the USB hub for M+KB and a 1080p webcam+mic, so I'm well under the 480Mbit limit).
It's a 2020 model, and they've updated it since then (the version listed on their website is 27UP850-W), but I don't think the panel itself has changed notably. I'd also recommend turning off the HDR support, especially if you're using it as a computer monitor -- all it seems to do is blow out reds and blues while undercooking greens.