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Re:The Life of MS-DOS by shadowofneptune on Sunday February 13, 2022 @09:14PM (#30327725)
If it uses it. Later versions of DOS did very little with the features the 386 offered, which is why there were MS-DOS extenders.

https://en.m.wikipedia.org/wiki/DOS_extender

Re:The Life of MS-DOS by ok123456 on Sunday February 13, 2022 @11:18PM (#30328323)
You can make your own minimal DOS Extender just by setting those registers. This is what some games did.