Good luck bootstrapping your first Kovarex U235 units!

A properly done Kovarex U235 takes about 2-hours to bootstrap itself. By this point in the game, you need to be able to "predict" how the factory will work in 2+ hours of latency and make sure things work as expected. (Or I guess you can blueprint copy/paste from an internet forum... but I find that "my own designs" are what make Factorio fun)

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Once you're able to "predict" how the factory works in 2, 3, 4 hour scales, a lot of good designs open up. You focus on throughput and *eventual* designs... willing to wait 3 hours to get things done.

And by "wait", I mean go play somewhere else for those 2 hours. There's always more work to do, a design that takes 3 hours to complete _AUTOMATICALLY_, but only 5 minutes of manual / human input is superior to a design that takes 10-minutes of human effort but completes in 15 minutes.

The #1 resource in Factorio is player-attention. You should be laying out designs, and then _LEAVING_ in most situations. You let the bots complete the area and come back to "verify" when they're done.