Well, that hasn't really been scientifically established, has it? It could simply be an illusion - just because I had a transcendental experience, then I woke up the next day feeling amazing, doesn't necessarily mean the transcendental experience caused me to feel amazing. No doubt there is some truth to it, as people report all kinds of life-affirming revelations that persist when sober, but we shouldn't exclude the possibility of psilocybin as a therapeutic drug in the traditional mould.
An experiment I would like to see is whether the positive after-effects of a macrodose are still measurable if the subject is unconscious the entire time. Helpfully, this would also blind the study, although a possible confounding factor is that medically rendering someone unconscious has after-effects of its own.
I have experienced the effects I talked about above with 300-500 mg doses of raw mushrooms. I don't know the amount of psilocybin... But that is a relatively small dose of mushrooms.
I would say microdosing should allow for the placebo to be effective. So yes, no visible effects. However, it doesn’t seem like they succeeded 100% on that.
It’s not that you take mushrooms and suddenly your anxiety decreases. It doesn’t give you anxiety immunity either…
I think it gives you the opportunity to see things from another perspective. If you can make use of this opportunity you can break down your conditioning and maybe free yourself from your anxiety.
It all depends on where you go with it in your head.