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Re:Psilocybin microdosing does not reduce symptoms of depres... by voski on Tuesday February 08, 2022 @12:43PM (#30261645)
I think the researchers don’t understand how it works.

It’s not that you take mushrooms and suddenly your anxiety decreases. It doesn’t give you anxiety immunity either…

I think it gives you the opportunity to see things from another perspective. If you can make use of this opportunity you can break down your conditioning and maybe free yourself from your anxiety.

It all depends on where you go with it in your head.

Re:Psilocybin microdosing does not reduce symptoms of depres... by dTal on Tuesday February 08, 2022 @03:09PM (#30263877)
If you're taking enough mushrooms to "see things from another perspective", that's not microdosing, that's regular dosing.
Re:Psilocybin microdosing does not reduce symptoms of depres... by ajkdhcb2 on Tuesday February 08, 2022 @07:40PM (#30267013)
Indeed people tend to define microdosing as a dose without a mind-altering trip. The benefits largely come from the trip itself, rather than the trip being a side-effect, so this could be a fruitless venture. I think it is obviously silly that people expect to be able to divorce the effects from the trip. It is still an extremely interesting question to ask what effects come from small sub-perceptual doses of psychedelics.
Re:Psilocybin microdosing does not reduce symptoms of depres... by dTal on Wednesday February 09, 2022 @07:38AM (#30271911)
>The benefits largely come from the trip itself, rather than the trip being a side-effect

Well, that hasn't really been scientifically established, has it? It could simply be an illusion - just because I had a transcendental experience, then I woke up the next day feeling amazing, doesn't necessarily mean the transcendental experience caused me to feel amazing. No doubt there is some truth to it, as people report all kinds of life-affirming revelations that persist when sober, but we shouldn't exclude the possibility of psilocybin as a therapeutic drug in the traditional mould.

An experiment I would like to see is whether the positive after-effects of a macrodose are still measurable if the subject is unconscious the entire time. Helpfully, this would also blind the study, although a possible confounding factor is that medically rendering someone unconscious has after-effects of its own.

Re:Psilocybin microdosing does not reduce symptoms of depres... by voski on Tuesday February 08, 2022 @04:05PM (#30264692)
Hmm not sure I agree with you. You can see things from another perspective when you are completely sober...
Re:Psilocybin microdosing does not reduce symptoms of depres... by culopatin on Tuesday February 08, 2022 @03:52PM (#30264526)
What you propose doesn’t seem to be microdosing. But it seems like what you’re saying is not so much about the drug but about the opportunity
Re:Psilocybin microdosing does not reduce symptoms of depres... by voski on Tuesday February 08, 2022 @04:02PM (#30264652)
I do understand that they are talking about micro dosing. I suppose I don't really know what the definition of micro dosing is. Is it taking something and not crossing the threshold for it to have any effects? If so what would the point of that be... Is it taking the minimum amount to pass the threshold?

I have experienced the effects I talked about above with 300-500 mg doses of raw mushrooms. I don't know the amount of psilocybin... But that is a relatively small dose of mushrooms.

Re:Psilocybin microdosing does not reduce symptoms of depres... by culopatin on Tuesday February 08, 2022 @04:06PM (#30264695)
Hey btw sorry I changed my message last minute. I realized I sounded like an asshole so I edited it.

I would say microdosing should allow for the placebo to be effective. So yes, no visible effects. However, it doesn’t seem like they succeeded 100% on that.

Re:Psilocybin microdosing does not reduce symptoms of depres... by glial on Tuesday February 08, 2022 @02:22PM (#30263191)
Interesting. I wonder if CBT + mushrooms is more effective than either separately.