I use uBlock for my laptop browser, and Safari content blocking on my phone, and have looked into stuff at the router level. I don't disable ad-blocking for any site.

The issue is primarily with mobile apps, which don't support ad-blockers and serve ads from their domains. I just found out about Nitter the other day, and didn't realize that you could now use Instagram/DMs from a web browser instead of using the app, so I will try that going forward.

This possibly affects things like YouTube recommendations too, not ads - I use it logged out and mostly search for music but if right now I open the site my top recommendation is a meme video "no amount of therapy will make this scene ok". I don't see any cookies and am not sure how to reset whatever session id for a fresh start.