This is exactly what I’ve seen with serious enterprise applications. Where users perform some complex task all day in the software. “User Preferences” are first order feature inclusions. They vary across global levels and down to specific feature settings. I’ve seen multiple occasions of customized layout/grid solutions.

One random thing I’ve wondered is if Excel power users end up implementing a ton of preference customizations. Otherwise it seems like a very well equipped “default-only” UX.