Re:DNA Mutations Do Not Occur Randomly – Discovery Transform...
by dekhn on Monday January 31, 2022 @11:47AM
(#30150064)
That's a great summary. If you want to go further, I think it's only really addressed in the literature and not much in textbooks.
The one interesting bit that I studied/researched and attempted to publish (no luck) was the observation that organisms that have RNAi, a process by which cells detect double-stranded RNA inside and eliminate it (likely a virus), tend to have fewer overlapping genes. When two different overlapping genes are transcribed to mRNA, they can form duplexes that kinda sorta look like viral RNA and get taken out by the RNAi surveillance system, even though they're legit transcripts.
The one interesting bit that I studied/researched and attempted to publish (no luck) was the observation that organisms that have RNAi, a process by which cells detect double-stranded RNA inside and eliminate it (likely a virus), tend to have fewer overlapping genes. When two different overlapping genes are transcribed to mRNA, they can form duplexes that kinda sorta look like viral RNA and get taken out by the RNAi surveillance system, even though they're legit transcripts.