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Re:Alphabet's Calico has begun trials on a molecule for neur... by PragmaticPulp on Friday January 21, 2022 @04:48PM (#30030437)
I was debating whether or not to post some of those self-experiments.

I'm aware of a couple more forums where people tried ISRIB and still claim to have lasting problems from it. One group was led by professional chemists who seemed like they knew what they were doing when it comes to testing and validating the product was pure.

It's amazing what people can access now, but self-experimentation with these compounds is a terrible idea.

Re:Alphabet's Calico has begun trials on a molecule for neur... by treeman79 on Friday January 21, 2022 @05:42PM (#30030908)
Developed a weird dementia at 39. Doctors Spent 2 years trying every prescription drug they could think of. Almost everything made matters worse. In some cases drastically. Complete nightmare. Those are with approved ones. Scary to try experiential.

Eventually learned it was a blood disorder and a simple blood thinner was the answer.

Re:Alphabet's Calico has begun trials on a molecule for neur... by nefitty on Friday January 21, 2022 @07:30PM (#30031790)
Wow. It sounds like you're better and hope you're better! That's an incredible story. Good on you for not giving up. You just lit a fire under my butt.
Re:Alphabet's Calico has begun trials on a molecule for neur... by cma on Saturday January 22, 2022 @02:19AM (#30034475)
Which blood disorder?
Re:Alphabet's Calico has begun trials on a molecule for neur... by treeman79 on Saturday January 22, 2022 @07:58AM (#30036256)
Factor 5 Leiden. I clot easily. So mini strokes. Turns out tiny clots don’t show up on MRIs.
Re:Alphabet's Calico has begun trials on a molecule for neur... by texasbigdata on Saturday January 22, 2022 @02:46PM (#30040158)
Very interested in this. So your c-reactive protein, d-dimer (sp?), etc etc showed negative? How did you find the clots? When you say "tiny", in medical terms do you mean mili or micro meters (I think that's right).

You might like the #1 book on Amazon under cardiology currently. Its thesis is cholesterol has nothing to do with heart diseases, its all in the clots. Good detail of the clotting process and relatively understandable.

Re:Alphabet's Calico has begun trials on a molecule for neur... by treeman79 on Saturday January 22, 2022 @05:15PM (#30041350)
Had a Pulmary embolism. Was gasping for air and coughing up flecks of blood. At the Er the Blood work was perfect. D-dimer, everything. Genetic testing came back positive later on. So they put on blood thinners. A few days later my dementia was gone. Was solving complex programming problems with ease once more.

Every time I try and go off them all the symptoms come back. So it was this that micro-clots was determined.

Also when drawing blood nurses kept complaining that my blood clots to fast.

Re:Alphabet's Calico has begun trials on a molecule for neur... by dennisgorelik on Saturday January 22, 2022 @10:11AM (#30037336)
How did you learn it was a blood disorder?
Re:Alphabet's Calico has begun trials on a molecule for neur... by tomComb on Friday January 21, 2022 @05:47PM (#30030956)
> It's amazing what people can access now, but self-experimentation with these compounds is a terrible idea.

I think it depends what the alternative is. If you have something like Alzheimer’s and no other alternatives, maybe self-experimentation is not such a bad idea.

Re:Alphabet's Calico has begun trials on a molecule for neur... by meowface on Friday January 21, 2022 @05:09PM (#30030610)
Reminds me a bit of cerebrolysin self-experiments I've read. It can either permanently make you smarter or permanently give you brain damage. Or both, perhaps.

(For anyone unaware, it's a bunch of neuropeptides harvested from pig brains that you typically either inject or - fittingly, due to the source - snort directly into your brain through your nose.)

Re:Alphabet's Calico has begun trials on a molecule for neur... by texasbigdata on Saturday January 22, 2022 @04:02AM (#30034982)
"Smarter" do you mean neuroregenesis? As I understood it's used post stroke to try to reverse some of the damage.