Maybe I’m interpreting the article wrong but it looks like they’re going to try temporarily activating a handful of transcription factors (Yamanaka) through a crispr mediated gene alteration/insertion.

I suppose if you created a viral vector that injected an mRNA with a nuclear localization signal - what would you use to activate it? Include a steroid promoter (or other) and co-inject with cortisone? None of my prediction needs crispr though so i don’t think that’s what they’ll do.

They’ll also need to address cellular debris/degradation products as well as gene issues. I’m sure lipofuscin, anthracotic plaque, tau tangles, amyloid plaques, oxidative damage, non-enzymatic glycosylation, etc will all ultimately need to be addressed.

I hope they do skin first, I’m tired of looking like a wrinkle.