Re:Those who'd had Covid-19 less likely than vaxxed to be in...
by esyir on Wednesday January 19, 2022 @09:47PM
(#30003800)
Are you surprised that they recommend vaccines though? Even if natural immunity gave absolutely perfect immunity, it would make sense to recommend vaccines to the uninfected population.
Re:Those who'd had Covid-19 less likely than vaxxed to be in...
by peteradio on Wednesday January 19, 2022 @09:56PM
(#30003893)
I believe they go further than that, recommending vaccine to anyone unvaccinated (not just uninfected+unvaccinated). I may have misread, I don't think the study they present really justifies that reach as the difference between vaccinated and not vaccinated is not statistically significant when someone has already recovered. That is per their own evaluation as I've read it.
I find the final paragraph amazing of the mmwr:
> Among the two cohorts with a previous COVID-19 diagnosis, no consistent incidence gradient by time since the previous diagnosis was observed (Supplementary Figure 3, https://stacks.cdc.gov/view/cdc/113253). When the vaccinated cohorts were stratified by the vaccine product received, among vaccinated persons without a previous COVID-19 diagnosis, the highest incidences were observed among persons receiving the Janssen (Johnson & Johnson), followed by Pfizer-BioNTech, then Moderna vaccines (Supplementary Figure 4, https://stacks.cdc.gov/view/cdc/113253). No pattern by product was observed among vaccinated persons with a previous COVID-19 diagnosis.
1) Natural immunity did not appear to wane over the study interval. (No difference in Hazard Ratio when stratifying by time since infection)
2) Vaccine only immunity showed major differences stratified across brands and time but if the person also had prior exposure then all differences disappear. Seems to indicate natural immunity is the heavy lifter here.
Of course they go on to blanket recommend vaccines but of course that was going to be the conclusion somehow.