Yup, I even wrote a framework to convert F# to javascript which allowed me to create a new (really powerful) validation provider for MVC. Sadly I haven't had a real world project that fit it well, so it's kind of gone by the wayside.

It's fairly straight forward to use with MVC, though it's less than ideal. You basically need to have a C# MVC project that referneces your F# projects (these would contain your controllers etc.)