Mr. Schlueter writes "you don’t compile it to target a given platform," as if this would be an advantage or a justification for existing ... when it's really quite the opposite.

I don't know when "order of magnitude difference" became a synonym for "worthwhile difference"

I didn't see Schlueter arguing either of these things, but we may have read the post differently. Both points, in my view, seemed only to illustrate that the JS-Assembly analogy is wrong, not to argue against to-JS languages.