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Re:Ctcctcggcgggcacgtag is unique to both SARS-CoV-2 and Mode... by dnautics on Friday January 14, 2022 @03:22PM (#29939869)
the mutation rate simply is not as high as you imagine it to be. If it were, then we would (likely) see more wobbling around the wobble pairs in the cleavage site coding region.
Re:Ctcctcggcgggcacgtag is unique to both SARS-CoV-2 and Mode... by ausername42027 on Friday January 14, 2022 @03:38PM (#29940096)
I never mentioned mutation rate so your gotcha is not as crafty as you might think. Also a mutation in the sense you seem to be implying (random base pair changes due to lack of proof reading) is not really what I am talking about. I am talking about HIV-1 genome being incorporated into SARS-CoV-2 by the host cell or either virus during replication. That is not that crazy when you have quadrillion of replication cycles and a selective pressure to mutate and incorporate new RNA.
Re:Ctcctcggcgggcacgtag is unique to both SARS-CoV-2 and Mode... by dnautics on Friday January 14, 2022 @03:41PM (#29940134)
we're talking about the odds of the founder event. My guess is odds are about 1 in 3^{5-6} (3-ish wobble options, five to six wobble sites, haven't looked at the sequence to confirm this. Probably someone can do a better analysis based on codon usage in humans. I suggest doing it as an exercise in understanding molecular biology.
Re:Ctcctcggcgggcacgtag is unique to both SARS-CoV-2 and Mode... by jacquesm on Saturday January 15, 2022 @11:00AM (#29947352)
Besides an enormous number of people now infected with both HIV and COVID-19. That alone increases the chances of this happening naturally enormously.
Re:Ctcctcggcgggcacgtag is unique to both SARS-CoV-2 and Mode... by drekk on Friday January 14, 2022 @03:31PM (#29939996)
my favorite part about your response here is how you didn't answer any of the questions and gave a hand-wavey response about how they're wrong.
Re:Ctcctcggcgggcacgtag is unique to both SARS-CoV-2 and Mode... by dnautics on Friday January 14, 2022 @03:38PM (#29940083)
alright, do you want a specific answer? My guess is it's somewhere around one in 3^{5-6}-ish, for the singular founder event that establishes and fixes that sequence as the canonical sequence for the furin cleavage site of COVID-19.