The advantage of highly multiplayer-centric games is that they are easier to protect against piracy; either by requiring an account to play online (which can be terminated) or by preventing identical CD keys from playing simultaneously. This can be circumvented by playing on a LAN or using Hamachi, but both solutions only work well with a specific coordinated group.

Spore's creature sharing multiplayer is easily sidestepped by piracy; it's possible to download all the user-created creatures via torrent post release. As that's the only multiplayer component of the game, there's very little difference in terms of piracy between Spore and any other single-player focused game.