Or the systems that don't think about that don't think about it because it doesn't matter one way or an other towards efficiency. There is such a thing as overthinking the interface.

The efficiency of well formatted data plus SQL or a sweet, sweet UNIX pipeline is so stupidly efficient compared to using Excel for the same task for any amount of data worth mentioning isn't even measured in units of orders-of-magnitude-better. Font and color selection doesn't even come into play with some user experience situations, and programs that attempt to control that when it doesn't make sense to seem petty and illfocused from the real goal.