Re:U.S. surgeons transplant pig heart into human patient
by Finnucane on Monday January 10, 2022 @05:37PM
(#29883882)
The article states they changed a sugar that triggered rejection.
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Re:U.S. surgeons transplant pig heart into human patient
by pazimzadeh on Monday January 10, 2022 @05:48PM
(#29884025)
Exactly:
"More than 95% of human anti-pig antibodies are directed against 3 pig carbohydrates: Gal 1 to 3αGal (≈80%–90%), Neu5Gc (≈5%–15%), and β4Gal (1%–5%)"
"To reduce anti-pig antibody binding to the xenograft, the 3 principal carbohydrate antigen targets have each been successfully removed from pigs by gene knockout (KO) (Figure 3)"
Progress Toward Cardiac Xenotransplantation https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7990044/