MySQL doesn't have a UUID type, nor 128-bit int type. But MySQL 8 does provide functions UUID_TO_BIN and BIN_TO_UUID, which make it trivial to convert between the human-readable string representation of a UUID and the more efficient BINARY(16) representation.

MariaDB now has a native UUID column type as of MariaDB 10.7. This is brand new -- 10.7 had its RC release in Nov, not GA yet but very soon I'd imagine.