On the other hand, if you make the trusses large enough and give an /attic/crawl access you could go up there and do the thing without needing to renovate. Then all center walls are non structural and you can move them as you please.
Come to think of it, I might build a house like this.
You can also leave the mechanical on the outside and not cover it too. I guess there's a certain beauty to me in the robot parts but I don't think many would like that.
You can also get away with ugly ceilings more easily when they are higher. A drop ceiling 8 feet or less from the floor is an eyesore. At 12 feet up it’s a lot less noticeable. Of course if you have very high ceilings you can often just leave them uncovered and have a more industrial aesthetic. You have to be more intentional about routing all the utilities then.
If you build with trusses for floors instead of joists, you can get a lot of the same benefits as a drop ceiling without the ugliness. You can run plumbing/vents/whatever though the trusses without destroying the whole ceiling to get access. You might not need to cut into the ceiling at all depending on what you’re doing and what existing access you have (e.g. an unfinished utility space may allow access to supply new power cables).
Of course patching the ceiling is hardly a big concern if you’re talking about a structure surviving for 1000 years.