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A comment on Omicron Has Potential to Stop the Pandemic, but That's Not the End of the Story. Parent comment

Re:Omicron Has Potential to Stop the Pandemic, but That's No... by netizen-936824 on Tuesday January 04, 2022 @11:13AM (#29796411)
Different manufacturers use different compounds at different concentrations. What do you mean "you can't switch"?

Plenty of people are getting moderna boosters after the first two being pfizer

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Re:Omicron Has Potential to Stop the Pandemic, but That's No... by tsol on Tuesday January 04, 2022 @12:55PM (#29797663)
What I meant is you won't develop separate antibody responses to each individual vaccine. You can mix and match the initial vaccine and boosters, and it'll strengthen your immune response. You just can't switch and expect the same response as someone taking that particular vaccine for the first time
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Re:Omicron Has Potential to Stop the Pandemic, but That's No... by netizen-936824 on Tuesday January 04, 2022 @01:32PM (#29798191)
>separate antibody responses

Of course not, they use the same mRNA. There's no reason to suspect they would in the first place.

The difference in response in the degree/intensity of response to the detected antigen. This is due to the concentration of mRNA in the vaccine (and therefore the concentration of antigen produced by the vaccine)

Moderna creates a greater response than Pfizer due to concentration (100mcg vs 30mcg). I don't think there's a reason to believe that a moderna booster on top of a Pfizer initial vaccination would not increase the degree of response when an actual infection is detected. Immunology is not my field however so my knowledge is a bit limited.

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