It's really not that bad. Homebrew may have fewer packages than, say, Debian's apt repo, but I still don't use 99% of the packages in either, and both cover everything I need.

Consider what exactly you'll be using in your stack, and go from there. I've had zero problems over the years using OS X for Rails, Python, node.js, and C++ development that was seeing deployment on Linux (typically Debian or Ubuntu, sometimes CentOS).