AWS doesn't follow their own advice about hosting multi-regional so every time us-east-1 has significant issues pretty much every AZ and region is affected.

Specifically large parts of the management API, and IAM service are seemingly centrally hosted in us-east-1.

If your infrastructure is static you'll largely avoid the fallout, but if you rely on API calls or dynamically created resources you can get caught in the blast regardless of region

Seems enough services in us-east-1 are down to cause most apps to fail. My simple app uses 10s of AWS services, at least some of which are out.

I may have seen more of these posts than you. The last one I saw where “AWS is down” was us-west-1.

Would be cool if this wasn't the region where AWS hosts their internals, making other regions unusable, right?

It's like my grandma saying "Honey, the internet is broken again." xD