There are products and studies now with Liraglutide and semaglutide, which show consistent and maintainable weight loss, but neither has been on the market for 5 years yet afaik, and the longest study only ran for 2 yearsit seems. Though it seems likely sustainable results from a 2 year study will hold for 5 years.

https://www.europeanpharmaceuticalreview.com/news/165203/weg...