I have been fascinated by this question ever since seeing an all apple school employ macbooks as a minimum bar. using Samsung dex, and now budget arm chromebooks I have found most websites do work on even mediatek and qualcomm chips, and design my own experiences to work there accordingly. The lenovo Duet is an incredible device, its sad how poorly optimized some of the heavier websites are and you can't do anything about it.

I find the bias towards powerful desktops as the only place any apps are written and tested ridiculous and something we can work to correct long term with progressive web.