> Amazon has oodles of expensive and difficult-to-replicate physical infrastructure, hordes of low-level staff, exclusive supply contracts aplenty, enough cash reserves to price-dump anybody into oblivion, and probably many other things I don’t even know I don’t know about.

The playbook to disrupt this was made clear when AirBNB disrupted, or at least bit a good chunk out of, the hotel industry, which could have been described in very similar terms. And they didn't have to replicate any of their physical infrastructure to do it.

Shopify, BigCommerce, and similar players are already doing it to Amazon. I predict this trend will continue.