In this context I was recently pointed to the story of Marek's disease [0], which went from a "quite low death rate" to "100% lethal" in a few decades. I think it's worth to know about this and have a long, hard think about the potential consequences of universal, non-sterilising vaccination. We might be locking ourselves into a situation with no escape.

[0] https://en.wikipedia.org/wiki/Marek%27s_disease#Prevention