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Re:Some experts suggest Omicron variant may have evolved in ... by hcjrmemeld on Thursday December 02, 2021 @01:34PM (#29420319)
Regarding 1., scientists already did this. This is how we know which mutations in Omicron are concerning, and which are not.

They basically tried a wide range of possible mutations and tested the effect on vaccine/infection antibodies:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7676316/

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