I was very excited to find Thomas Weise had wrangled latex and a Tex Live installation into a docker container: https://github.com/thomasWeise/docker-texlive-thin
Another useful tool is latexmk, which is already installed inside the docker-texlive-thin container : https://mg.readthedocs.io/latexmk.html
By containing the madness of latex tooling and package management with docker and some volume mounts, I could have a reasonably sane build process to manufacture PDFs from latex source files.
I don't recommend md2blog add mandatory dependencies on anything related to latex. Another way to think about it might be offering optional latex support through some md2blog plugin mechanism that doesn't know anything about latex. But that path sure won't produce anything resembling a "zero config" static site generator! Might end up with something closer to apache httpd.
If so, that might be something I could look into. Version 1 of md2blog actually did almost exactly that for Graphviz diagrams (but I removed that feature because, frankly, I didn't understand the Graphviz license). A quick look indicates that Latex also has its own unique license that is... quite lengthy.