Been there, done that (except the "killed" part). It was in a heavy fog. I was doing well to find a street at all, and it turned out to be one way the wrong way (the only such street in town). I figured it out when I saw wall-to-wall headlights coming at me out of the fog, and made a fast move for the curb...

So, yeah. People react. Which brings up the question: How well do self-driving AIs respond to a wrong-way driver? How well do self-driving AIs recover when they are the wrong-way driver, and they suddenly have enough data to realize that?