As to "home use", personally I'm successfully keeping my dotfiles & $HOME/bin/ scripts managed with Nix + home-manager. Becomes useful when changing jobs, and also makes it easier to share new config tricks between work & home machine. Regardless if Linux or Mac.

edit: in particular, going just Nix (not NixOS) on work machine(s) allows me to fall back to apt-get/brew quickly when a particular tool is not (yet) on Nixpkgs.