Europeans and Native Americans interacted. They observed each other. They talked to each other. For quite some time.

Kondiaronk [0] was a highly respected chief, statesman, and political philosophizer. Louis Armand de Lom d’Arce spent time in North America and wrote a book based on his dialogs with Kondiaronk [1]. This book was famous for a while. It contrasted the freedom and justice Indians had for themselves with the injustice of Christianity, subjugation to lords, and the problems associated with money and other facets of the European way of life. The book precipitated a lot of philosophical soul searching, an off-shoot of which was the idea of the "noble savage", which was used to eventually discount any ideas these primitives had as irrelevant to civilized modern people.

I'm not sure if I understand your comment. Are you saying that Kondiaronk would not have known how Indians lived?

[0] https://en.wikipedia.org/wiki/Kondiaronk

[1] https://en.wikipedia.org/wiki/New_Voyages_to_North_America

I wouldn't think that the spread of smallpox invalidates what he said, just because things may have been different in the past, maybe for his tribe, maybe not so much. I'm sure that he would have known if a disease drastically changed his culture a hundred years prior.

Even before smallpox there was quite a variety of native cultures, Kondiaronk being Huron, who were quite different than the Inca and Aztec, for example. He probably would have criticized them, also.