> For example, if I change some accessibility settings on the OS level, all UI elements in all apps implementing truly native UI components would inherit the OS-level settings. The toggle button on iOS could be set to have an I and an O for the ON and OFF state. A web-based app would not respect that setting.

There's no reason (in theory) that electron shouldn't support something like that, and it could (and should) be fixed at the electron layer, which would be ideal!