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Re:Pyjion – A Python JIT Compiler by pabloem on Tuesday November 09, 2021 @05:51AM (#29160020)
From FAQ[1]:

> IronPython is an implementation of Python that is implemented using .NET. While IronPython tries to be usable from within .NET, Pyjion does not have a compatibility story with .NET. This also means IronPython cannot use C extension modules while Pyjion can.

[1] https://github.com/tonybaloney/pyjion#ironpython

Re:Pyjion – A Python JIT Compiler by qalmakka on Tuesday November 09, 2021 @08:41AM (#29161579)
So it basically uses .NET in place of something like, LLVM, in order to generate native code. Clever.