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Re:Pfizer's oral Covid-19 antiviral cuts hospitalization, de... by SideburnsOfDoom on Friday November 05, 2021 @05:42PM (#29125026)
Yes, This trend is true anywhere in the world that has mass vaccination, e.g. UK: https://www.youtube.com/watch?v=Hc7A1bVuSJU&t=56s

IDK why anyone would deny this observable reality.

Re:Pfizer's oral Covid-19 antiviral cuts hospitalization, de... by angelzen on Friday November 05, 2021 @08:27PM (#29126217)
The linked video, https://www.youtube.com/watch?v=Hc7A1bVuSJU&t=56s, is misleading. It shows that the number of unvax cases is much larger than vax cases. I hope that by know it is common knowledge that the pandemic behaves very differently between age groups. Simpson's paradox abounds. The video only breaks down vax/unvax for aggregate numbers. This is a smell.

UK publishes the vax/unvax numbers broken down by age groups. See Table 2 in https://assets.publishing.service.gov.uk/government/uploads/.... Raw numbers:

  cases between week 40 and week 43 2021
             unvax      vax   1dose
  under 18  336893      818   36000
  18-29      24097    33649    9500
  30-39      25832    71492    7800
  40-49      15717   130686    4500
  50-59       6701    99722    2000
  60-69       2484    56779     800
  70-79        917    34305     300
    ≥80        471    12339     200
1. In every age group, except under 18, the number of vax cases is larger than the number of unvax cases, contradicting the video on its face.

2. Under 18 has a large case number, which dominates the totals. Some issues:

2.1. Schools have strict testing and tracing policies. The large case numbers may simply an effect of higher testing rates for the respective population.

2.2. Related to 2.1., there are two ways to count cases: PCR cases and symptomatic cases. In case of large case numbers outliers, the difference between the two measures can explain a large difference, though it is impossible to independently verify that a consistent measure was applied for all age groups.

2.3. Vaccination in 12-17 was only recently introduced. VE decreases over time. Studies disagrees by how much. At six months time, for Pfizer I've seen 55%-75%, from a high of 90%. Closer to the vaccination event VE is higher, thus the number of vax cases is temporarily lower. A more realistic assessment assessment ought to a. break down under 18 in to 0-5, 5-11, 12-17, and wait 6 months post vaccination campaign. Note that VE is also a somewhat misleading metric, 90% means 9/10 case reduction, 50% merely 1/2; a small percentage drop in VE at the high values mean a large increase in cases.

3. In some age categories, e.g. 50-59, unvax share of the cases is as small as 6%. Not sure (*) what the unvax rate in UK is for that age group, the reports says somewhere in the low teens, that number has been contested. But 6% is low enough by itself. If that doesn't make you wonder about the official line "unvaccinated people were 6.8 times more likely to get COVID-19 than fully vaccinated people.", then nothing will ever do.

Can't speak about US data because US is, for some reason, very tight lipped when it comes to publishing basic epi data with breakdown by date, age and vax status. If you have a link to the equivalent of the UK PHE vaccine surveillance report for any US state, please share.

(*) Apparently UK is not sure about the vax rates either, because apparently UK doesn't know how many people of a given age live in the country. That is a story for another time.

Re:Pfizer's oral Covid-19 antiviral cuts hospitalization, de... by SideburnsOfDoom on Saturday November 06, 2021 @08:59AM (#29129850)
Thanks for linking to that report, it's interesting reading, particularly the part with "We present data on COVID-19 cases, hospitalisations and deaths by vaccination status. These raw data should not be used to estimate vaccine effectiveness" (that sentence occurs twice so tat you don't miss it)

This is of course exactly what you did above.

It also says "We have published a blog to accompany this section of the vaccine surveillance report" https://ukhsa.blog.gov.uk/2021/11/02/transparency-and-data-u...

You should not expect ZOE study data to match UK Govt data exactly, they use different methods and check different symptoms. This is that theme that Prof. Spector talks about often.

Re:Pfizer's oral Covid-19 antiviral cuts hospitalization, de... by angelzen on Saturday November 06, 2021 @11:28AM (#29131022)
"should not be used to estimate vaccine effectiveness"

Exactly. Neither should aggregate numbers that various US states and Prof. Spector use to spread fear, acrimony and stigma should be used to estimate VE, or mislead the audiences to estimate VE by themselves. Notice how the ZOE video you linked lacks the intellectual honesty to display the same disclaimer. His own website says "Incidence estimates were updated on 21 July 2021.". He's basically fabricating numbers, for all we know just as accurate as Prof. Ferguson. This is no better than the "antivax garbage" some people are so keen on summarily calling out.

Here are some longish term studies and preprints for Pfizer's VE against infection.

UK, 3 months VEaI = 75%. https://www.nature.com/articles/s41591-021-01548-7

Qatar, 3 months VEaI = 70%, 6 months VEaI = 12.8%, https://www.nejm.org/doi/full/10.1056/NEJMoa2114114

Sweden, <50yo, 2-4 months VEaI = 83%, 4-6 months VEaI = 50%, https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3949410

US, veterans, 3 months VEaI = 78%, 6 months VEaI = 50%, https://www.medrxiv.org/content/10.1101/2021.04.20.21254636v...

Two notes:

* VE against infection drops over time. Sadly, I am not aware of any reliable literature for VE after 9 or 12 months. Unfortunately Pfizer killed their own critical trials, which had a solid headstart, by vaccinating the control arm after 6 months. But the trend is clear, and worrisome.

* 80% VE => 1:5 infection odds. 75% VE => 1:4 infection odds. 50% VE => 1:2 infection odds. 12% VE, it's a wash. Numbers like 1:6.8 infection odds this long after the vaccination campaign are fantasy.

Re:Pfizer's oral Covid-19 antiviral cuts hospitalization, de... by SideburnsOfDoom on Saturday November 06, 2021 @11:49AM (#29131204)
> Prof. Spector use to spread fear, acrimony and stigma should be used to estimate VE, or mislead the audiences ... lacks the intellectual honesty

This is a very bold partisan claim, in fact it is insult. It comes across as another Paranoid fantasy out of US politics, irrelevant to the UK. I'm no longer interested in anything that you have to say. Good day.

Re:Pfizer's oral Covid-19 antiviral cuts hospitalization, de... by angelzen on Saturday November 06, 2021 @12:27PM (#29131557)
This ZOE business is something else. Their website is 75% building up their credentials, 25% promoting their app and 0% substance, e.g. what the actual formulas are or a link to code and data dumps. Or at least a research publication with some details. Perhaps there is a link hidden somewhere, but neither their Home, About or FAQ point to it.

They literally changed their formula because the trends in the unvaccinated population didn't to conform to their prior biases. Though the formula details are still a mystery.

"Last week, we reported a plateau in new COVID cases based on our methods at the time, which relied on a small number of unvaccinated people in our dataset compared with the wider UK population. The number of daily new cases in the unvaccinated group appeared to be dropping which in turn resulted in our overall numbers trending down. This meant the figures were accurate to our dataset but didn’t represent the full picture in the UK."

https://covid.joinzoe.com/post/covid-estimates-updated-vacci...

I'll grant that UK has no vaccine mandates (including for kids!) and none of the craziness. Have a great one!